Cargo adaptors regulate stepping and force generation of mammalian dynein-dynactin

Cytoplasmic dynein is an ATP-driven motor that transports intracellular cargos along microtubules. Dynein adopts an inactive conformation when not attached to cargo, and motility is activated when dynein assembles with dynactin and a cargo adaptor. It remained unclear how active dynein-dynactin comp...

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Detalles Bibliográficos
Autores principales: Elshenawy, Mohamed M., Canty, John T., Oster, Liya, Ferro, Luke S., Zhou, Zhou, Blanchard, Scott C., Yildiz, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810841/
https://www.ncbi.nlm.nih.gov/pubmed/31501589
http://dx.doi.org/10.1038/s41589-019-0352-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810841/
https://www.ncbi.nlm.nih.gov/pubmed/31501589
http://dx.doi.org/10.1038/s41589-019-0352-0

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