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Cargo adaptors regulate stepping and force generation of mammalian dynein-dynactin
Cytoplasmic dynein is an ATP-driven motor that transports intracellular cargos along microtubules. Dynein adopts an inactive conformation when not attached to cargo, and motility is activated when dynein assembles with dynactin and a cargo adaptor. It remained unclear how active dynein-dynactin comp...
Autores principales: | Elshenawy, Mohamed M., Canty, John T., Oster, Liya, Ferro, Luke S., Zhou, Zhou, Blanchard, Scott C., Yildiz, Ahmet |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810841/ https://www.ncbi.nlm.nih.gov/pubmed/31501589 http://dx.doi.org/10.1038/s41589-019-0352-0 |
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