675. Efficacy of Human-Simulated Bronchopulmonary Exposures of Cefepime and Zidebactam (WCK 5222) Against Multidrug-Resistant (MDR) Pseudomonas aeruginosa (PSA) in a Neutropenic Murine Pneumonia Model

BACKGROUND: WCK 5222 combines cefepime (FEP) with zidebactam (ZID), a bicycloacyl hydrazide β-lactam enhancer which binds PBP2 in PSA and inhibits class A and C β-lactamases. The in vivo efficacy of human-simulated bronchopulmonary exposures of WCK 5222 against MDR PSA, a recalcitrant pneumonia-caus...

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Detalles Bibliográficos
Autores principales: Kidd, James M, Abdelraouf, Kamilia, Nicolau, David P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810914/
http://dx.doi.org/10.1093/ofid/ofz360.743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810914/
http://dx.doi.org/10.1093/ofid/ofz360.743

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