615. Daptomycin (DAP) Synergy with β-Lactams in DAP-Resistant (DAP-R) E. faecium (Efm) Is Dependent On PBP5 Sequence and β-Lactam-binding Affinity

BACKGROUND: DAP in combination with β-lactams is a viable option to treat recalcitrant DAP-R/tolerant strains of Efm. Ampicillin (AMP), ceftaroline (CPT), and ertapenem (ERT) have the best synergism. Using a DAP tolerant strain (503; DAP MIC 2 µg/mL) of Efm, we previously showed that AMP, CPT, and E...

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Detalles Bibliográficos
Autores principales: Khan, Ayesha, Kebriaei, Razieh, Singh,, Kavindra V, Murray, Barbara E, Rybak, Michael J, Arias, Cesar A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811106/
http://dx.doi.org/10.1093/ofid/ofz360.683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811106/
http://dx.doi.org/10.1093/ofid/ofz360.683

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