Cargando…

The expression of the insulin receptor in gastric cancer correlates with the HER2 status and may have putative therapeutic implications

BACKGROUND: Metabolic reprogramming in gastric cancer (GC) involves not only an alteration of glucose metabolism, but also of insulin receptor (IR) expression. We investigated if (1) GCs express the IR in cancer cells (CC-IR) and vasculature (VIR), (2) IR expression is clinically relevant and may be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heckl, Steffen M., Wiesener, Viva, Behrens, Hans-Michael, Ulase, Dita, Krüger, Sandra, Röcken, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811372/ https://www.ncbi.nlm.nih.gov/pubmed/30989432 http://dx.doi.org/10.1007/s10120-019-00964-6

Ejemplares similares

LAG3 in gastric cancer: it’s complicated
por: Ulase, Dita, et al.
Publicado: (2023)

Gastric Carcinomas with Stromal B7-H3 Expression Have Lower Intratumoural CD8+ T Cell Density
por: Ulase, Dita, et al.
Publicado: (2021)

SMARCA4 and SMARCE1 in gastric cancer: Correlation with ARID1A, and microsatellite stability, and SMARCE1 / ERBB2 co‐amplification
por: Pries, Katharina, et al.
Publicado: (2023)

Neoadjuvant/Perioperative Treatment Affects Spatial Distribution and Densities of Tumor Associated Neutrophils and CD8+ Lymphocytes in Gastric Cancer
por: Hoffmann, Anne, et al.
Publicado: (2021)

The putative pleiotropic functions of meprin β in gastric cancer
por: Siemsen, Wiebke, et al.
Publicado: (2023)

Epithelial insulin receptor expression–prognostic relevance in colorectal cancer
por: Heckl, Steffen M., et al.
Publicado: (2018)

Troy is expressed in human stomach mucosa and a novel putative prognostic marker of intestinal type gastric cancer
por: Wilhelm, Franziska, et al.
Publicado: (2016)

Insulin Receptor in Pancreatic Cancer—Crown Witness in Cross Examination
por: Heckl, Steffen M., et al.
Publicado: (2021)

Questioning the IGF1 receptor’s assigned role in CRC – a case for rehabilitation?
por: Heckl, Steffen M., et al.
Publicado: (2020)

The novel negative checkpoint regulator VISTA is expressed in gastric carcinoma and associated with PD-L1/PD-1: A future perspective for a combined gastric cancer therapy?
por: Böger, Christine, et al.
Publicado: (2017)

Clinicopathological characteristics of RHOA mutations in a Central European gastric cancer cohort
por: Röcken, Christoph, et al.
Publicado: (2016)

Sexual dimorphism in gastric cancer: tumor-associated neutrophils predict patient outcome only for women
por: Clausen, Franziska, et al.
Publicado: (2019)

The tumor biological significance of RNF43 and LRP1B in gastric cancer is complex and context-dependent
por: Holm, Bente, et al.
Publicado: (2023)

FGFR2 overexpression and compromised survival in diffuse-type gastric cancer in a large central European cohort
por: Schrumpf, Thorben, et al.
Publicado: (2022)

Expression of the potential therapeutic target claudin-18.2 is frequently decreased in gastric cancer: results from a large Caucasian cohort study
por: Dottermusch, Matthias, et al.
Publicado: (2019)

PD-L1 is an independent prognostic predictor in gastric cancer of Western patients
por: Böger, Christine, et al.
Publicado: (2016)

MET in gastric cancer – discarding a 10% cutoff rule
por: Metzger, Marie‐Luise, et al.
Publicado: (2015)

Clinicopathologic Characteristics of Microsatellite Instable Gastric Carcinomas Revisited: Urgent Need for Standardization
por: Mathiak, Micaela, et al.
Publicado: (2017)

Intratumoral heterogeneity affects tumor regression and Ki67 proliferation index in perioperatively treated gastric carcinoma
por: Kock am Brink, Magnus, et al.
Publicado: (2022)

HER2/neu testing in primary colorectal carcinoma
por: Ingold Heppner, B, et al.
Publicado: (2014)

Ki67—An unsuitable marker of gastric cancer prognosis unmasks intratumoral heterogeneity
por: Böger, Christine, et al.
Publicado: (2015)

Expression of LGR5, FZD7, TROY, and MIST1 in Perioperatively Treated Gastric Carcinomas and Correlation with Therapy Response
por: Freiin Grote, Antonia, et al.
Publicado: (2019)

Therapy Resistance in Neoadjuvantly Treated Gastric Cancer and Cancer of the Gastroesophageal Junction is Associated with an Increased Expression of Immune Checkpoint Inhibitors—Comparison Against a Therapy Naïve Cohort
por: Schoop, Hauke, et al.
Publicado: (2019)

Her2/neu testing in gastric cancer: evaluating the risk of sampling errors
por: Warneke, V. S., et al.
Publicado: (2013)

Hepatic myofibroblasts exert immunosuppressive effects independent of the immune checkpoint regulator PD-L1 in liver metastasis of pancreatic ductal adenocarcinoma
por: Beckinger, Silje, et al.
Publicado: (2023)

Reproducibility of Her2/neu scoring in gastric cancer and assessment of the 10% cut-off rule
por: Behrens, Hans-Michael, et al.
Publicado: (2015)

Programmed Death-Ligand 1 (PD-L1) Expression Is Induced by Insulin in Pancreatic Ductal Adenocarcinoma Cells Pointing to Its Role in Immune Checkpoint Control
por: Heckl, Steffen M., et al.
Publicado: (2021)

Ambulacrarian insulin-related peptides and their putative receptors suggest how insulin and similar peptides may have evolved from insulin-like growth factor
por: Veenstra, Jan A.
Publicado: (2021)

Amyloid in biopsies of the gastrointestinal tract—a retrospective observational study on 542 patients
por: Freudenthaler, Sophie, et al.
Publicado: (2016)

Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine
por: Röcken, Christoph, et al.
Publicado: (2021)

Expression and role of the immune checkpoint regulator PD-L1 in the tumor-stroma interplay of pancreatic ductal adenocarcinoma
por: Daunke, Tina, et al.
Publicado: (2023)

The Spatial Distribution of LGR5(+) Cells Correlates With Gastric Cancer Progression
por: Simon, Eva, et al.
Publicado: (2012)

HER2 testing in gastric cancer: results of a German expert meeting
por: Lordick, Florian, et al.
Publicado: (2017)

Epstein–Barr virus-associated gastric cancer reveals intratumoral heterogeneity of PIK3CA mutations
por: Böger, C., et al.
Publicado: (2017)

Interpreting whole genome and exome sequencing data of individual gastric cancer samples
por: Esser, Daniela, et al.
Publicado: (2017)

Integrins α(v)β(3) and α(v)β(5) as prognostic, diagnostic, and therapeutic targets in gastric cancer
por: Böger, Christine, et al.
Publicado: (2014)

Chromosomal Instability in Gastric Cancer Biology
por: Maleki, Saffiyeh Saboor, et al.
Publicado: (2017)

Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis
por: Warneke, V S, et al.
Publicado: (2013)

Massive uterine fibroid: a diagnostic dilemma: a case report and review of the literature
por: Viva, Wiesener, et al.
Publicado: (2021)

Predictive biomarkers in gastric cancer
por: Röcken, C.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_o8rdh2gc10h5tm8hq6re5d6dca