Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling

Despite the crowded nature of the cellular milieu, ligand–GPCR–G protein interactions are traditionally viewed as spatially and temporally isolated events. In contrast, recent reports suggest the spatial and temporal coupling of receptor–effector interactions, with the potential to diversify downstr...

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Detalles Bibliográficos
Autores principales: Gupte, Tejas M., Ritt, Michael, Dysthe, Matthew, Malik, Rabia U., Sivaramakrishnan, Sivaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811539/
https://www.ncbi.nlm.nih.gov/pubmed/31645561
http://dx.doi.org/10.1038/s41467-019-12755-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811539/
https://www.ncbi.nlm.nih.gov/pubmed/31645561
http://dx.doi.org/10.1038/s41467-019-12755-9

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