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Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex

Sensory hypersensitivity is a common and debilitating feature of neurodevelopmental disorders such as Fragile X Syndrome (FXS). How developmental changes in neuronal function culminate in network dysfunction that underlies sensory hypersensitivities is unknown. By systematically studying cellular an...

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Detalles Bibliográficos
Autores principales: Domanski, Aleksander P. F., Booker, Sam A., Wyllie, David J. A., Isaac, John T. R., Kind, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811545/
https://www.ncbi.nlm.nih.gov/pubmed/31645553
http://dx.doi.org/10.1038/s41467-019-12736-y