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Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection

Central nervous system (CNS) injuries persist for years, and currently there are no therapeutics that can address the complex injury cascade that develops over this time-scale. 17β-estradiol (E2) has broad tropism within the CNS, targeting and inducing beneficial phenotypic changes in myriad cells f...

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Detalles Bibliográficos
Autores principales: D’Amato, Anthony R., Puhl, Devan L., Ellman, Samuel A. T., Balouch, Bailey, Gilbert, Ryan J., Palermo, Edmund F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811552/
https://www.ncbi.nlm.nih.gov/pubmed/31645570
http://dx.doi.org/10.1038/s41467-019-12835-w