CRISPR-Cas12a Nucleases Bind Flexible DNA Duplexes without RNA/DNA Complementarity

[Image: see text] Cas12a (also known as “Cpf1”) is a class 2 type V-A CRISPR-associated nuclease that can cleave double-stranded DNA at specific sites. The Cas12a effector enzyme comprises a single protein and a CRISPR-encoded small RNA (crRNA) and has been used for genome editing and manipulation....

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Wei, Singh, Jaideep, Allen, Aleique, Li, Yue, Kathiresan, Venkatesan, Qureshi, Omair, Tangprasertchai, Narin, Zhang, Xiaojun, Parameshwaran, Hari Priya, Rajan, Rakhi, Qin, Peter Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811856/
https://www.ncbi.nlm.nih.gov/pubmed/31656887
http://dx.doi.org/10.1021/acsomega.9b01469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811856/
https://www.ncbi.nlm.nih.gov/pubmed/31656887
http://dx.doi.org/10.1021/acsomega.9b01469

Ejemplares similares