Synthesis of New Cu Complex Based on Natural 5Z,9Z-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line

[Image: see text] The complex (bipy)(2)Cu(5,9-eicd) was prepared by the reaction of Cu(OAc)(2) with 5Z,9Z-eicosadienoic acid and 2,2′-bipyridine in methanol. The new copper complex showed high antitumor activity in vitro toward A2780cis, A2780, Hek293, K562, HL60, Jurkat, and U937 cell lines and eff...

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Detalles Bibliográficos
Autores principales: Dzhemileva, Lilya U., D’yakonov, Vladimir A., Dil’mukhametova, Leisan K., Dzhemilev, Usein M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812112/
https://www.ncbi.nlm.nih.gov/pubmed/31656933
http://dx.doi.org/10.1021/acsomega.9b02756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812112/
https://www.ncbi.nlm.nih.gov/pubmed/31656933
http://dx.doi.org/10.1021/acsomega.9b02756

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