Synthesis of New Cu Complex Based on Natural 5Z,9Z-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line

[Image: see text] The complex (bipy)(2)Cu(5,9-eicd) was prepared by the reaction of Cu(OAc)(2) with 5Z,9Z-eicosadienoic acid and 2,2′-bipyridine in methanol. The new copper complex showed high antitumor activity in vitro toward A2780cis, A2780, Hek293, K562, HL60, Jurkat, and U937 cell lines and eff...

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Detalles Bibliográficos
Autores principales: Dzhemileva, Lilya U., D’yakonov, Vladimir A., Dil’mukhametova, Leisan K., Dzhemilev, Usein M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812112/
https://www.ncbi.nlm.nih.gov/pubmed/31656933
http://dx.doi.org/10.1021/acsomega.9b02756
Descripción
Sumario:[Image: see text] The complex (bipy)(2)Cu(5,9-eicd) was prepared by the reaction of Cu(OAc)(2) with 5Z,9Z-eicosadienoic acid and 2,2′-bipyridine in methanol. The new copper complex showed high antitumor activity in vitro toward A2780cis, A2780, Hek293, K562, HL60, Jurkat, and U937 cell lines and efficiently inhibited human topoisomerase I. Using flow cytofluorometry, (bipy)(2)Cu(5,9-eicd) was studied for the effect on the cell cycle and apoptosis-inducing activity in tumor cells.

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