Synthesis of New Cu Complex Based on Natural 5Z,9Z-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line

[Image: see text] The complex (bipy)(2)Cu(5,9-eicd) was prepared by the reaction of Cu(OAc)(2) with 5Z,9Z-eicosadienoic acid and 2,2′-bipyridine in methanol. The new copper complex showed high antitumor activity in vitro toward A2780cis, A2780, Hek293, K562, HL60, Jurkat, and U937 cell lines and eff...

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Autores principales: Dzhemileva, Lilya U., D’yakonov, Vladimir A., Dil’mukhametova, Leisan K., Dzhemilev, Usein M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812112/
https://www.ncbi.nlm.nih.gov/pubmed/31656933
http://dx.doi.org/10.1021/acsomega.9b02756
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author Dzhemileva, Lilya U.
D’yakonov, Vladimir A.
Dil’mukhametova, Leisan K.
Dzhemilev, Usein M.
author_facet Dzhemileva, Lilya U.
D’yakonov, Vladimir A.
Dil’mukhametova, Leisan K.
Dzhemilev, Usein M.
author_sort Dzhemileva, Lilya U.
collection PubMed
description [Image: see text] The complex (bipy)(2)Cu(5,9-eicd) was prepared by the reaction of Cu(OAc)(2) with 5Z,9Z-eicosadienoic acid and 2,2′-bipyridine in methanol. The new copper complex showed high antitumor activity in vitro toward A2780cis, A2780, Hek293, K562, HL60, Jurkat, and U937 cell lines and efficiently inhibited human topoisomerase I. Using flow cytofluorometry, (bipy)(2)Cu(5,9-eicd) was studied for the effect on the cell cycle and apoptosis-inducing activity in tumor cells.
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spelling pubmed-68121122019-10-25 Synthesis of New Cu Complex Based on Natural 5Z,9Z-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line Dzhemileva, Lilya U. D’yakonov, Vladimir A. Dil’mukhametova, Leisan K. Dzhemilev, Usein M. ACS Omega [Image: see text] The complex (bipy)(2)Cu(5,9-eicd) was prepared by the reaction of Cu(OAc)(2) with 5Z,9Z-eicosadienoic acid and 2,2′-bipyridine in methanol. The new copper complex showed high antitumor activity in vitro toward A2780cis, A2780, Hek293, K562, HL60, Jurkat, and U937 cell lines and efficiently inhibited human topoisomerase I. Using flow cytofluorometry, (bipy)(2)Cu(5,9-eicd) was studied for the effect on the cell cycle and apoptosis-inducing activity in tumor cells. American Chemical Society 2019-10-11 /pmc/articles/PMC6812112/ /pubmed/31656933 http://dx.doi.org/10.1021/acsomega.9b02756 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Dzhemileva, Lilya U.
D’yakonov, Vladimir A.
Dil’mukhametova, Leisan K.
Dzhemilev, Usein M.
Synthesis of New Cu Complex Based on Natural 5Z,9Z-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line
title Synthesis of New Cu Complex Based on Natural 5Z,9Z-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line
title_full Synthesis of New Cu Complex Based on Natural 5Z,9Z-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line
title_fullStr Synthesis of New Cu Complex Based on Natural 5Z,9Z-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line
title_full_unstemmed Synthesis of New Cu Complex Based on Natural 5Z,9Z-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line
title_short Synthesis of New Cu Complex Based on Natural 5Z,9Z-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line
title_sort synthesis of new cu complex based on natural 5z,9z-eicosadienoic acid: effective topoisomerase i inhibitor and cytotoxin against the cisplatin-resistant cell line
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812112/
https://www.ncbi.nlm.nih.gov/pubmed/31656933
http://dx.doi.org/10.1021/acsomega.9b02756
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