Cardiac toxicity of Triptergium wilfordii Hook F. may correlate with its inhibition to hERG channel

Tripterygium wilfordii Hook F. (TWHF) is a Chinese traditional medicine with cardiac toxicities. However, the mechanism of acute cardiac toxicity is not very clear. By using patch clamp techniques, we found that 0.05 mg/ml and 0.1 mg/ml of the aqueous crude extract of TWHF inhibit 21.4 ± 1.6% and 86...

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Detalles Bibliográficos
Autores principales: Zhao, Wei, Xiao, Liping, Pan, Lanying, Ke, Xianfu, Zhang, Yanting, Zhong, Dian, Xu, Jianwei, Cao, Fumin, Wu, Liren, Chen, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812191/
https://www.ncbi.nlm.nih.gov/pubmed/31667381
http://dx.doi.org/10.1016/j.heliyon.2019.e02527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812191/
https://www.ncbi.nlm.nih.gov/pubmed/31667381
http://dx.doi.org/10.1016/j.heliyon.2019.e02527

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