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Two CRISPR/Cas9-mediated methods for targeting complex insertions, deletions, or replacements in mouse
Genetically modified model organisms are valuable tools for probing gene function, dissecting complex signaling networks, studying human disease, and more. CRISPR/Cas9 technology has significantly democratized and reduced the time and cost of generating genetically modified models to the point that...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812322/ https://www.ncbi.nlm.nih.gov/pubmed/31667107 http://dx.doi.org/10.1016/j.mex.2019.09.003 |