Rapid, direct, and sensitive determination of aziridine and 2-chloroethylamine by hydrophilic interaction liquid chromatography-mass spectrometry

A rapid HILIC-MS method was developed for measuring the genotoxic impurities aziridine and 2-chloroethylamine. Sample preparation was simple and direct without requiring derivatization. Paired with a 1.5 min isocratic UHPLC separation, sample analysis could be completed in less than 5 min. Linearity...

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Detalles Bibliográficos
Autor principal: Shackman, Jonathan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812333/
https://www.ncbi.nlm.nih.gov/pubmed/31667117
http://dx.doi.org/10.1016/j.mex.2019.09.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812333/
https://www.ncbi.nlm.nih.gov/pubmed/31667117
http://dx.doi.org/10.1016/j.mex.2019.09.017

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