Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis
INTRODUCTION: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. MATERIALS AND METHODS: We evaluated HEV seroprevalence...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812777/ https://www.ncbi.nlm.nih.gov/pubmed/31648288 http://dx.doi.org/10.1371/journal.pone.0224404 |
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author | Fantilli, Anabella C. Trinks, Julieta Marciano, Sebastián Zárate, Fabián Balderramo, Domingo C. Wassaf, Maribel G. Martínez Haddad, Leila Gadano, Adrián Debes, José D. Pisano, María B. Ré, Viviana E. |
author_facet | Fantilli, Anabella C. Trinks, Julieta Marciano, Sebastián Zárate, Fabián Balderramo, Domingo C. Wassaf, Maribel G. Martínez Haddad, Leila Gadano, Adrián Debes, José D. Pisano, María B. Ré, Viviana E. |
author_sort | Fantilli, Anabella C. |
collection | PubMed |
description | INTRODUCTION: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. MATERIALS AND METHODS: We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72). RESULTS: The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4–15.99); p<0.05]. HEV seropositivity was significantly higher in alcohol-related cirrhosis compared to other causes of cirrhosis [39.5% vs. 12.4%; OR = 4.71; (95% CI = 1.9–11.6); p<0.05] and to healthy controls [OR = 15.7; (95% CI = 6.8–36.4); p = 0.0001]. The HEV seroprevalence in alcoholic-related cirrhosis vs. with alcohol use disorder was 39.5% vs. 12.5% [OR = 4.58; (95% CI = 1.81–11.58); p<0.001]. CONCLUSION: We found a high seroprevalence of HEV in patients with cirrhosis and in individuals with alcohol use disorder. The simultaneous presence of both factors (cirrhosis + alcohol) showed more association to HEV infection. Larger studies with prospective follow up are needed to further clarify this interaction. |
format | Online Article Text |
id | pubmed-6812777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-68127772019-11-03 Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis Fantilli, Anabella C. Trinks, Julieta Marciano, Sebastián Zárate, Fabián Balderramo, Domingo C. Wassaf, Maribel G. Martínez Haddad, Leila Gadano, Adrián Debes, José D. Pisano, María B. Ré, Viviana E. PLoS One Research Article INTRODUCTION: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. MATERIALS AND METHODS: We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72). RESULTS: The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4–15.99); p<0.05]. HEV seropositivity was significantly higher in alcohol-related cirrhosis compared to other causes of cirrhosis [39.5% vs. 12.4%; OR = 4.71; (95% CI = 1.9–11.6); p<0.05] and to healthy controls [OR = 15.7; (95% CI = 6.8–36.4); p = 0.0001]. The HEV seroprevalence in alcoholic-related cirrhosis vs. with alcohol use disorder was 39.5% vs. 12.5% [OR = 4.58; (95% CI = 1.81–11.58); p<0.001]. CONCLUSION: We found a high seroprevalence of HEV in patients with cirrhosis and in individuals with alcohol use disorder. The simultaneous presence of both factors (cirrhosis + alcohol) showed more association to HEV infection. Larger studies with prospective follow up are needed to further clarify this interaction. Public Library of Science 2019-10-24 /pmc/articles/PMC6812777/ /pubmed/31648288 http://dx.doi.org/10.1371/journal.pone.0224404 Text en © 2019 Fantilli et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Fantilli, Anabella C. Trinks, Julieta Marciano, Sebastián Zárate, Fabián Balderramo, Domingo C. Wassaf, Maribel G. Martínez Haddad, Leila Gadano, Adrián Debes, José D. Pisano, María B. Ré, Viviana E. Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis |
title | Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis |
title_full | Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis |
title_fullStr | Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis |
title_full_unstemmed | Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis |
title_short | Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis |
title_sort | unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812777/ https://www.ncbi.nlm.nih.gov/pubmed/31648288 http://dx.doi.org/10.1371/journal.pone.0224404 |
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