Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis

INTRODUCTION: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. MATERIALS AND METHODS: We evaluated HEV seroprevalence...

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Autores principales: Fantilli, Anabella C., Trinks, Julieta, Marciano, Sebastián, Zárate, Fabián, Balderramo, Domingo C., Wassaf, Maribel G. Martínez, Haddad, Leila, Gadano, Adrián, Debes, José D., Pisano, María B., Ré, Viviana E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812777/
https://www.ncbi.nlm.nih.gov/pubmed/31648288
http://dx.doi.org/10.1371/journal.pone.0224404
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author Fantilli, Anabella C.
Trinks, Julieta
Marciano, Sebastián
Zárate, Fabián
Balderramo, Domingo C.
Wassaf, Maribel G. Martínez
Haddad, Leila
Gadano, Adrián
Debes, José D.
Pisano, María B.
Ré, Viviana E.
author_facet Fantilli, Anabella C.
Trinks, Julieta
Marciano, Sebastián
Zárate, Fabián
Balderramo, Domingo C.
Wassaf, Maribel G. Martínez
Haddad, Leila
Gadano, Adrián
Debes, José D.
Pisano, María B.
Ré, Viviana E.
author_sort Fantilli, Anabella C.
collection PubMed
description INTRODUCTION: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. MATERIALS AND METHODS: We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72). RESULTS: The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4–15.99); p<0.05]. HEV seropositivity was significantly higher in alcohol-related cirrhosis compared to other causes of cirrhosis [39.5% vs. 12.4%; OR = 4.71; (95% CI = 1.9–11.6); p<0.05] and to healthy controls [OR = 15.7; (95% CI = 6.8–36.4); p = 0.0001]. The HEV seroprevalence in alcoholic-related cirrhosis vs. with alcohol use disorder was 39.5% vs. 12.5% [OR = 4.58; (95% CI = 1.81–11.58); p<0.001]. CONCLUSION: We found a high seroprevalence of HEV in patients with cirrhosis and in individuals with alcohol use disorder. The simultaneous presence of both factors (cirrhosis + alcohol) showed more association to HEV infection. Larger studies with prospective follow up are needed to further clarify this interaction.
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spelling pubmed-68127772019-11-03 Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis Fantilli, Anabella C. Trinks, Julieta Marciano, Sebastián Zárate, Fabián Balderramo, Domingo C. Wassaf, Maribel G. Martínez Haddad, Leila Gadano, Adrián Debes, José D. Pisano, María B. Ré, Viviana E. PLoS One Research Article INTRODUCTION: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. MATERIALS AND METHODS: We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72). RESULTS: The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4–15.99); p<0.05]. HEV seropositivity was significantly higher in alcohol-related cirrhosis compared to other causes of cirrhosis [39.5% vs. 12.4%; OR = 4.71; (95% CI = 1.9–11.6); p<0.05] and to healthy controls [OR = 15.7; (95% CI = 6.8–36.4); p = 0.0001]. The HEV seroprevalence in alcoholic-related cirrhosis vs. with alcohol use disorder was 39.5% vs. 12.5% [OR = 4.58; (95% CI = 1.81–11.58); p<0.001]. CONCLUSION: We found a high seroprevalence of HEV in patients with cirrhosis and in individuals with alcohol use disorder. The simultaneous presence of both factors (cirrhosis + alcohol) showed more association to HEV infection. Larger studies with prospective follow up are needed to further clarify this interaction. Public Library of Science 2019-10-24 /pmc/articles/PMC6812777/ /pubmed/31648288 http://dx.doi.org/10.1371/journal.pone.0224404 Text en © 2019 Fantilli et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Fantilli, Anabella C.
Trinks, Julieta
Marciano, Sebastián
Zárate, Fabián
Balderramo, Domingo C.
Wassaf, Maribel G. Martínez
Haddad, Leila
Gadano, Adrián
Debes, José D.
Pisano, María B.
Ré, Viviana E.
Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis
title Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis
title_full Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis
title_fullStr Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis
title_full_unstemmed Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis
title_short Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis
title_sort unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812777/
https://www.ncbi.nlm.nih.gov/pubmed/31648288
http://dx.doi.org/10.1371/journal.pone.0224404
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