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Key residues in TLR4-MD2 tetramer formation identified by free energy simulations
Toll-like receptors (TLRs) play a central role in both the innate and adaptive immune systems by recognizing pathogen-associated molecular patterns and inducing the release of the effector molecules of the immune system. The dysregulation of the TLR system may cause various autoimmune diseases and s...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812856/ https://www.ncbi.nlm.nih.gov/pubmed/31609969 http://dx.doi.org/10.1371/journal.pcbi.1007228 |