β-blockers augment L-type Ca(2+) channel activity by targeting spatially restricted β(2)AR signaling in neurons

G protein-coupled receptors (GPCRs) transduce pleiotropic intracellular signals in mammalian cells. Here, we report neuronal excitability of β-blockers carvedilol and alprenolol at clinically relevant nanomolar concentrations. Carvedilol and alprenolol activate β(2)AR, which promote G protein signal...

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Detalles Bibliográficos
Autores principales: Shen, Ao, Chen, Dana, Kaur, Manpreet, Bartels, Peter, Xu, Bing, Shi, Qian, Martinez, Joseph M, Man, Kwun-nok Mimi, Nieves-Cintron, Madeline, Hell, Johannes W, Navedo, Manuel F, Yu, Xi-Yong, Xiang, Yang K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813027/
https://www.ncbi.nlm.nih.gov/pubmed/31609201
http://dx.doi.org/10.7554/eLife.49464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813027/
https://www.ncbi.nlm.nih.gov/pubmed/31609201
http://dx.doi.org/10.7554/eLife.49464

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