Physiologically Based Pharmacokinetic Models for Adults and Children Reveal a Role of Intracellular Tubulin Binding in Vincristine Disposition

Vincristine is a cytotoxic chemotherapeutic agent used as first‐line therapy for pediatric acute lymphocytic leukemia. It is cleared by hepatic oxidative metabolism by CYP3A4 and CYP3A5 and via hepatic (biliary) efflux mediated by P‐glycoprotein (P‐gp) transporter. Bottom‐up physiologically based ph...

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Detalles Bibliográficos
Autores principales: Lee, Christine M., Zane, Nicole R., Veal, Gareth, Thakker, Dhiren R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813170/
https://www.ncbi.nlm.nih.gov/pubmed/31420944
http://dx.doi.org/10.1002/psp4.12453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813170/
https://www.ncbi.nlm.nih.gov/pubmed/31420944
http://dx.doi.org/10.1002/psp4.12453

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