Cargando…

Methylprednisolone Decreases Mitochondria-Mediated Apoptosis and Autophagy Dysfunction in Hepatocytes of Experimental Autoimmune Hepatitis Model via the Akt/mTOR Signaling

Autoimmune hepatitis (AIH) is characterized by massive immune cell-mediated hepatocyte destruction. Glucocorticoids, particularly methylprednisolone (MP), are the most effective treatment for AIH; however, the mechanism underlying the effects of glucocorticoid treatment has not been fully elucidated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Xiaoli, Men, Ruoting, Wang, Haoran, Shen, Mengyi, Wang, Tingting, Ye, Tinghong, Luo, Xuefeng, Yang, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813226/ https://www.ncbi.nlm.nih.gov/pubmed/31680966 http://dx.doi.org/10.3389/fphar.2019.01189

Ejemplares similares

Critical roles of conventional dendritic cells in autoimmune hepatitis via autophagy regulation
por: Fan, Xiaoli, et al.
Publicado: (2020)

Induction of mitochondria-mediated apoptosis and PI3K/Akt/ mTOR-mediated autophagy by aflatoxin B(2) in hepatocytes of broilers
por: Chen, Binlong, et al.
Publicado: (2016)

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat
por: He, Yajun, et al.
Publicado: (2016)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
por: Zheng, Xiangjin, et al.
Publicado: (2021)

Roles of Macrophages and Exosomes in Liver Diseases
por: Shen, Mengyi, et al.
Publicado: (2020)

Methylprednisolone Inhibits Autophagy of Vascular Endothelial Cells in Rat Femoral Head Via PI3K/Akt/mTOR Pathway
por: Jang, Bo‐yong, et al.
Publicado: (2022)

Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes
por: Zheng, Xiao-yuan, et al.
Publicado: (2019)

Glucose Metabolism Reprogramming of Regulatory T Cells in Concanavalin A-Induced Hepatitis
por: Huang, Chen, et al.
Publicado: (2021)

Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation
por: Shen, Yi, et al.
Publicado: (2018)

Emodin-Induced Autophagy Against Cell Apoptosis Through the PI3K/AKT/mTOR Pathway in Human Hepatocytes [Corrigendum]
Publicado: (2022)

Apatinib-induced protective autophagy and apoptosis through the AKT–mTOR pathway in anaplastic thyroid cancer
por: Feng, Haoran, et al.
Publicado: (2018)

Dihydroartemisinin Induces Endothelial Cell Autophagy through Suppression of the Akt/mTOR Pathway
por: Liu, Jing, et al.
Publicado: (2019)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

Telomerase and mTOR in the brain: the mitochondria connection
por: Miwa, Satomi, et al.
Publicado: (2017)

Loss of pex5 sensitizes zebrafish to fasting due to deregulated mitochondria, mTOR, and autophagy
por: Bhandari, Sushil, et al.
Publicado: (2023)

YAP manipulates proliferation via PTEN/AKT/mTOR-mediated autophagy in lung adenocarcinomas
por: Xu, Wei, et al.
Publicado: (2021)

Prucalopride inhibits the glioma cells proliferation and induces autophagy via AKT-mTOR pathway
por: Qiao, Hong, et al.
Publicado: (2018)

The Roles of Autophagy, Mitophagy, and the Akt/mTOR Pathway in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps
por: Wang, Chen, et al.
Publicado: (2022)

Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma
por: Zhong, Chen, et al.
Publicado: (2019)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells
por: Li, Gaopan, et al.
Publicado: (2021)

Matrine induces autophagy in human neuroblastoma cells via blocking the AKT-mTOR pathway
por: Liu, Nanjing, et al.
Publicado: (2022)

Arctigenin Inhibits Glioblastoma Proliferation through the AKT/mTOR Pathway and Induces Autophagy
por: Jiang, Yong'an, et al.
Publicado: (2020)

FTO is required for myogenesis by positively regulating mTOR-PGC-1α pathway-mediated mitochondria biogenesis
por: Wang, Xiaobo, et al.
Publicado: (2017)

Concomitant Sjögren's Syndrome Was Not Associated with a Poorer Response or Outcomes in Ursodeoxycholic Acid-Treated Patients with Primary Biliary Cholangitis
por: Ni, Ping, et al.
Publicado: (2019)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

mTOR Pathways in Cancer and Autophagy
por: Paquette, Mathieu, et al.
Publicado: (2018)

Autophagy of macrophages is regulated by PI3k/Akt/mTOR signalling in the development of diabetic encephalopathy
por: Wang, Beiyun, et al.
Publicado: (2018)

Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy
por: Zhou, Jiao, et al.
Publicado: (2022)

Itaconate attenuates autoimmune hepatitis via PI3K/AKT/mTOR pathway-mediated inhibition of dendritic cell maturation and autophagy
por: Zhang, Qiyu, et al.
Publicado: (2023)

SOCS5 inhibition induces autophagy to impair metastasis in hepatocellular carcinoma cells via the PI3K/Akt/mTOR pathway
por: Zhang, Mao, et al.
Publicado: (2019)

Protocol for the assessment of mTOR activity in mouse primary hepatocytes
por: Plata-Gómez, Ana Belén, et al.
Publicado: (2021)

Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells
por: Gao, Likun, et al.
Publicado: (2019)

Valproic acid induces autophagy by suppressing the Akt/mTOR pathway in human prostate cancer cells
por: Xia, Qinghua, et al.
Publicado: (2016)

GSK343 induces autophagy and downregulates the AKT/mTOR signaling pathway in pancreatic cancer cells
por: Xu, Hao, et al.
Publicado: (2019)

AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts
por: Sanchez-Alvarez, Miguel, et al.
Publicado: (2017)

Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway
por: Huang, He, et al.
Publicado: (2018)

Valproic Acid Enhanced Apoptosis by Promoting Autophagy Via Akt/mTOR Signaling in Glioma
por: Han, Wei, et al.
Publicado: (2020)

Apatinib induces apoptosis and autophagy via the PI3K/AKT/mTOR and MAPK/ERK signaling pathways in neuroblastoma
por: Yu, Xiying, et al.
Publicado: (2020)

Ivermectin induces autophagy-mediated cell death through the AKT/mTOR signaling pathway in glioma cells
por: Liu, Jingjing, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_34gpfm6ggc922t7jpvk8oiev0o