Lysosome restoration to activate podocyte autophagy: a new therapeutic strategy for diabetic kidney disease

Autophagy, the intracellular lysosomal degradation process plays a pivotal role in podocyte homeostasis in diabetic kidney disease (DKD). Lysosomal function, autophagic activity, and their actions were investigated in vitro and in vivo. We found that LC3-II- and p62-positive vacuoles accumulated in...

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Detalles Bibliográficos
Autores principales: Liu, Wei Jing, Gan, Yu, Huang, Wei Fang, Wu, Hong-luan, Zhang, Xue-qin, Zheng, Hui Juan, Liu, Hua-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813305/
https://www.ncbi.nlm.nih.gov/pubmed/31649253
http://dx.doi.org/10.1038/s41419-019-2002-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813305/
https://www.ncbi.nlm.nih.gov/pubmed/31649253
http://dx.doi.org/10.1038/s41419-019-2002-6

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