Cargando…

Lysosome restoration to activate podocyte autophagy: a new therapeutic strategy for diabetic kidney disease

Autophagy, the intracellular lysosomal degradation process plays a pivotal role in podocyte homeostasis in diabetic kidney disease (DKD). Lysosomal function, autophagic activity, and their actions were investigated in vitro and in vivo. We found that LC3-II- and p62-positive vacuoles accumulated in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Wei Jing, Gan, Yu, Huang, Wei Fang, Wu, Hong-luan, Zhang, Xue-qin, Zheng, Hui Juan, Liu, Hua-feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813305/ https://www.ncbi.nlm.nih.gov/pubmed/31649253 http://dx.doi.org/10.1038/s41419-019-2002-6

Ejemplares similares

Vitamin D/VDR Protects Against Diabetic Kidney Disease by Restoring Podocytes Autophagy
por: Song, Zhixia, et al.
Publicado: (2021)

Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes
por: Xiong, Jing, et al.
Publicado: (2013)

Blockage of the lysosome-dependent autophagic pathway contributes to complement membrane attack complex-induced podocyte injury in idiopathic membranous nephropathy
por: Liu, Wei Jing, et al.
Publicado: (2017)

Podocytes Degrade Endocytosed Albumin Primarily in Lysosomes
por: Carson, John M., et al.
Publicado: (2014)

Podocyte Lysosome Dysfunction in Chronic Glomerular Diseases
por: Li, Guangbi, et al.
Publicado: (2020)

Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease
por: Liu, Xue-qi, et al.
Publicado: (2021)

Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity
por: Trudeau, Kyle M., et al.
Publicado: (2016)

Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy
por: Liu, Na, et al.
Publicado: (2017)

Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes
por: Li, Xueling, et al.
Publicado: (2020)

Puerarin Restores Autophagosome-Lysosome Fusion to Alleviate Cadmium-Induced Autophagy Blockade via Restoring the Expression of Rab7 in Hepatocytes
por: Wang, Tao, et al.
Publicado: (2021)

Podocyte Autophagy in Homeostasis and Disease
por: Lin, Qisheng, et al.
Publicado: (2021)

Vitamin D Ameliorates Podocyte Injury by Enhancing Autophagy Activity in Diabetic Kidney Disease
por: Zhang, Xiaoyi, et al.
Publicado: (2023)

Understanding Podocyte Biology to Develop Novel Kidney Therapeutics
por: Lal, Mark A., et al.
Publicado: (2018)

Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling
por: Zhang, Chuyue, et al.
Publicado: (2017)

Connexin 43-autophagy loop in the podocyte injury of diabetic nephropathy
por: Ji, Jialing, et al.
Publicado: (2019)

Lysosomal dysfunction–induced autophagic stress in diabetic kidney disease
por: Zheng, Hui Juan, et al.
Publicado: (2020)

Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
por: Zeng, Jialiu, et al.
Publicado: (2023)

Disturbance of autophagy-lysosome signaling molecule expression in human gastric adenocarcinoma
por: WEI, SHAO-HUA, et al.
Publicado: (2014)

Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential
por: Zhang, Wei, et al.
Publicado: (2022)

Down-regulation of Risa improves podocyte injury by enhancing autophagy in diabetic nephropathy
por: Su, Pei-Pei, et al.
Publicado: (2022)

Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians
por: Xiao, Fu-Hui, et al.
Publicado: (2018)

HDAC4 blocks autophagy to trigger podocyte injury: non-epigenetic action in diabetic nephropathy
por: Wei, Qingqing, et al.
Publicado: (2014)

Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2021)

Podocytes maintain high basal levels of autophagy independent of mtor signaling
por: Bork, Tillmann, et al.
Publicado: (2019)

Lysosome biology in autophagy
por: Yim, Willa Wen-You, et al.
Publicado: (2020)

Apelin involved in progression of diabetic nephropathy by inhibiting autophagy in podocytes
por: Liu, Yu, et al.
Publicado: (2017)

Effect of Lacking ZKSCAN3 on Autophagy, Lysosomal Biogenesis and Senescence
por: Li, Xiao-Min, et al.
Publicado: (2023)

The Podocyte in Diabetic Kidney Disease
por: Stitt-Cavanagh, Erin, et al.
Publicado: (2009)

DRAM1 Regulates Autophagy Flux through Lysosomes
por: Zhang, Xing-Ding, et al.
Publicado: (2013)

C/EBPα deficiency in podocytes aggravates podocyte senescence and kidney injury in aging mice
por: Zhang, Liwen, et al.
Publicado: (2019)

Triptolide protects podocytes via autophagy in immunoglobulin A nephropathy
por: Liang, Shikai, et al.
Publicado: (2018)

Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney
por: Festa, Beatrice Paola, et al.
Publicado: (2018)

Autophagy Participates in Lysosomal Vacuolation-Mediated Cell Death in RGNNV-Infected Cells
por: Huang, Youhua, et al.
Publicado: (2020)

Podocyte Injury in Diabetic Kidney Disease: A Focus on Mitochondrial Dysfunction
por: Liu, Simeng, et al.
Publicado: (2022)

Catalpol Ameliorates Podocyte Injury by Stabilizing Cytoskeleton and Enhancing Autophagy in Diabetic Nephropathy
por: Chen, Yan, et al.
Publicado: (2019)

Podocyte-specific deletion of miR-146a increases podocyte injury and diabetic kidney disease
por: Li, Xiaobo, et al.
Publicado: (2022)

The Role of Podocytes and Podocyte-Associated Biomarkers in Diagnosis and Treatment of Diabetic Kidney Disease
por: Kravets, Igor, et al.
Publicado: (2020)

Autophagy Protects against Palmitic Acid-Induced Apoptosis in Podocytes in vitro
por: Jiang, Xu-shun, et al.
Publicado: (2017)

Dysregulated Autophagy Contributes to Podocyte Damage in Fabry’s Disease
por: Liebau, Max C., et al.
Publicado: (2013)

Vitamin D protects podocytes from autoantibodies induced injury in lupus nephritis by reducing aberrant autophagy
por: Yu, Qi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_r2qnfhg5pt8v3mfh8e0scskor3