Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations

The functional effect of a gene edit by designer nucleases depends on the DNA repair outcome at the targeted locus. While non-homologous end joining (NHEJ) repair results in various mutations, microhomology-mediated end joining (MMEJ) creates precise deletions based on the alignment of flanking micr...

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Detalles Bibliográficos
Autores principales: Grajcarek, Janin, Monlong, Jean, Nishinaka-Arai, Yoko, Nakamura, Michiko, Nagai, Miki, Matsuo, Shiori, Lougheed, David, Sakurai, Hidetoshi, Saito, Megumu K., Bourque, Guillaume, Woltjen, Knut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813315/
https://www.ncbi.nlm.nih.gov/pubmed/31649251
http://dx.doi.org/10.1038/s41467-019-12829-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813315/
https://www.ncbi.nlm.nih.gov/pubmed/31649251
http://dx.doi.org/10.1038/s41467-019-12829-8

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