Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs

[Image: see text] Off-tissue effects are persistent issues of modern inhibition-based therapies. By merging the strategies of photopharmacology and small-molecule degraders, we introduce a novel concept for persistent spatiotemporal control of induced protein degradation that potentially prevents of...

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Detalles Bibliográficos
Autores principales: Pfaff, Patrick, Samarasinghe, Kusal T. G., Crews, Craig M., Carreira, Erick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813558/
https://www.ncbi.nlm.nih.gov/pubmed/31660436
http://dx.doi.org/10.1021/acscentsci.9b00713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813558/
https://www.ncbi.nlm.nih.gov/pubmed/31660436
http://dx.doi.org/10.1021/acscentsci.9b00713

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