Cargando…
Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs
[Image: see text] Off-tissue effects are persistent issues of modern inhibition-based therapies. By merging the strategies of photopharmacology and small-molecule degraders, we introduce a novel concept for persistent spatiotemporal control of induced protein degradation that potentially prevents of...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2019
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813558/ https://www.ncbi.nlm.nih.gov/pubmed/31660436 http://dx.doi.org/10.1021/acscentsci.9b00713 |