Cytochrome P450 1A2 Is Incapable of Oxidizing Bilirubin Under Physiological Conditions

Background: Bilirubin (BR) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) through glucuronidation in the liver. Some studies have shown that several subtypes of cytochrome P450 (CYP) enzymes, including CYP1A2, are upregulated by inducers and proposed to be al...

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Detalles Bibliográficos
Autores principales: Li, Xinyi, Yu, Dongzhen, Jie, Huiqun, Zhou, Huiqun, Ye, Haibo, Ma, Guo, Wan, Lili, Li, Chunyan, Shi, Haibo, Yin, Shankai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813656/
https://www.ncbi.nlm.nih.gov/pubmed/31680983
http://dx.doi.org/10.3389/fphar.2019.01220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813656/
https://www.ncbi.nlm.nih.gov/pubmed/31680983
http://dx.doi.org/10.3389/fphar.2019.01220

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