TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling

We screen ion channels and transporters throughout the genome to identify those required by human melanoma cells but not by normal human melanocytes. We discover that Mucolipin-1 (MCOLN1), which encodes the lysosomal cation channel TRPML1, is preferentially required for the survival and proliferatio...

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Detalles Bibliográficos
Autores principales: Kasitinon, Stacy Y., Eskiocak, Ugur, Martin, Misty, Bezwada, Divya, Khivansara, Vishal, Tasdogan, Alpaslan, Zhao, Zhiyu, Mathews, Thomas, Aurora, Arin B., Morrison, Sean J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813770/
https://www.ncbi.nlm.nih.gov/pubmed/31461647
http://dx.doi.org/10.1016/j.celrep.2019.07.086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813770/
https://www.ncbi.nlm.nih.gov/pubmed/31461647
http://dx.doi.org/10.1016/j.celrep.2019.07.086

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