Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72.

Codon72 of human p53 gene is polymorphic, encoding arginine or proline. Here we report construction of a human p53 knock-in (Hupki) mouse encoding the codon72(pro) variant. The new strain was crossed with the original Hupki mice (codon72(arg/arg)) to obtain primary embryonic fibroblasts polymorphic...

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Detalles Bibliográficos
Autores principales: Reinbold, M, Luo, J-L, Nedelko, T, Jerchow, B, Murphy, ME, Whibley, C, Wei, Q, Hollstein, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813802/
https://www.ncbi.nlm.nih.gov/pubmed/17998932
http://dx.doi.org/10.1038/sj.onc.1210932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813802/
https://www.ncbi.nlm.nih.gov/pubmed/17998932
http://dx.doi.org/10.1038/sj.onc.1210932

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