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Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72.
Codon72 of human p53 gene is polymorphic, encoding arginine or proline. Here we report construction of a human p53 knock-in (Hupki) mouse encoding the codon72(pro) variant. The new strain was crossed with the original Hupki mice (codon72(arg/arg)) to obtain primary embryonic fibroblasts polymorphic...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813802/ https://www.ncbi.nlm.nih.gov/pubmed/17998932 http://dx.doi.org/10.1038/sj.onc.1210932 |