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Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis

BACKGROUND: Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease whose pathogenesis remains incompletely understood. Increasing evidence suggests that both genetic susceptibilities and changes in DNA methylation influence pivotal biological pathways and thereby contribute to the d...

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Detalles Bibliográficos
Autores principales: Lu, Tianyuan, Klein, Kathleen Oros, Colmegna, Inés, Lora, Maximilien, Greenwood, Celia M. T., Hudson, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813992/
https://www.ncbi.nlm.nih.gov/pubmed/31651337
http://dx.doi.org/10.1186/s12920-019-0602-8