Exploration of the selective binding mechanism of protein kinase Aurora A selectivity via a comprehensive molecular modeling study

BACKGROUND: The kinase of Aurora A has been regarded as a promising therapeutic target due to its altered expression in various human cancers. However, given the high similarity of the active binding site of Aurora A to other kinases, designing highly selective inhibitors towards Aurora A remains a...

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Detalles Bibliográficos
Autores principales: Zhang, Zhe, Xu, Yafei, Wu, Jian, Shen, Ying, Cheng, Hao, Xiang, Yiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814069/
https://www.ncbi.nlm.nih.gov/pubmed/31660263
http://dx.doi.org/10.7717/peerj.7832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814069/
https://www.ncbi.nlm.nih.gov/pubmed/31660263
http://dx.doi.org/10.7717/peerj.7832

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