Cargando…
Exploration of the selective binding mechanism of protein kinase Aurora A selectivity via a comprehensive molecular modeling study
BACKGROUND: The kinase of Aurora A has been regarded as a promising therapeutic target due to its altered expression in various human cancers. However, given the high similarity of the active binding site of Aurora A to other kinases, designing highly selective inhibitors towards Aurora A remains a...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
PeerJ Inc.
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814069/ https://www.ncbi.nlm.nih.gov/pubmed/31660263 http://dx.doi.org/10.7717/peerj.7832 |