Repurposing mechanistic insight of PDE-5 inhibitor in cancer chemoprevention through mitochondrial-oxidative stress intervention and blockade of DuCLOX signalling

BACKGROUND: This study evaluates the anti-cancer effects of Tadalafil (potent PDE-5 inhibitor) in female albino wistar rats against n-methyl n-nitrosourea induced mammary gland carcinogenesis. METHODS: The animals were selected and randomly divided among four groups and each group contains six anima...

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Detalles Bibliográficos
Autores principales: Singh, Manjari, Kasna, Sweta, Roy, Subhadeep, Aldosary, Sara, Saeedan, Abdulaziz S., Ansari, Mohd. Nazam, Kaithwas, Gaurav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814136/
https://www.ncbi.nlm.nih.gov/pubmed/31651285
http://dx.doi.org/10.1186/s12885-019-6152-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814136/
https://www.ncbi.nlm.nih.gov/pubmed/31651285
http://dx.doi.org/10.1186/s12885-019-6152-9

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