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P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib
The P16 (CDKN2A(ink4a)) gene is an endogenous CDK4/6 inhibitor. Palbociclib (PD0332991) is an anti-CDK4/6 chemical for cancer treatment. P16 is most frequently inactivated by copy number deletion and DNA methylation in cancers. It is well known that cancer cells with P16 deletion are more sensitive...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814222/ https://www.ncbi.nlm.nih.gov/pubmed/31652270 http://dx.doi.org/10.1371/journal.pone.0223084 |