Circulating cell-free DNA from plasma undergoes less fragmentation during bisulfite treatment than genomic DNA due to low molecular weight

BACKGROUND: Methylation patterns in circulating cell-free DNA are potential biomarkers for cancer and other pathologies. Currently, bisulfite treatment underpins most DNA methylation analysis methods, however, it is known to fragment DNA. Circulating DNA is already short, and further fragmentation d...

Descripción completa

Detalles Bibliográficos
Autores principales: Werner, Bonnita, Yuwono, Nicole Laurencia, Henry, Claire, Gunther, Kate, Rapkins, Robert William, Ford, Caroline Elizabeth, Warton, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814277/
https://www.ncbi.nlm.nih.gov/pubmed/31652288
http://dx.doi.org/10.1371/journal.pone.0224338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814277/
https://www.ncbi.nlm.nih.gov/pubmed/31652288
http://dx.doi.org/10.1371/journal.pone.0224338

Ejemplares similares