Cargando…

The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration

The protozoan parasite Toxoplasma gondii is thought to exploit monocyte trafficking to facilitate dissemination across endothelial barriers such as the blood-brain barrier. Here we analyzed the migration of parasitized monocytes in model endothelial and interstitial environments. We report that infe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Drewry, Lisa L, Jones, Nathaniel G, Wang, Quiling, Onken, Michael D, Miller, Mark J, Sibley, L David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814536/ https://www.ncbi.nlm.nih.gov/pubmed/31332383 http://dx.doi.org/10.1038/s41564-019-0504-8

Ejemplares similares

The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18
por: Behnke, Michael S., et al.
Publicado: (2012)

Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii
por: Behnke, Michael S., et al.
Publicado: (2015)

Toxoplasma gondii ROP16 kinase silences the cyclin B1 gene promoter by hijacking host cell UHRF1-dependent epigenetic pathways
por: Sabou, Marcela, et al.
Publicado: (2019)

Expression and Purification of Recombinant ROP1 of Toxoplasma gondii in Bacteria
por: Mohabati, Reyhaneh, et al.
Publicado: (2013)

ROP18 Is a Rhoptry Kinase Controlling the Intracellular Proliferation of Toxoplasma gondii
por: El Hajj, Hiba, et al.
Publicado: (2007)

Influenza Virus-Like Particles Presenting both Toxoplasma gondii ROP4 and ROP13 Enhance Protection against T. gondii Infection
por: Kang, Hae-Ji, et al.
Publicado: (2019)

Transepithelial Migration of Toxoplasma gondii Is Linked to Parasite Motility and Virulence
por: Barragan, Antonio, et al.
Publicado: (2002)

Toxoplasma gondii Superinfection and Virulence during Secondary Infection Correlate with the Exact ROP5/ROP18 Allelic Combination
por: Jensen, Kirk D. C., et al.
Publicado: (2015)

Sequence Variation in Toxoplasma gondii rop17 Gene among Strains from Different Hosts and Geographical Locations
por: Zhang, Nian-Zhang, et al.
Publicado: (2014)

Hijacking of host mitochondria by Toxoplasma gondii and SARS-CoV-2
por: Zhang, Ruize, et al.
Publicado: (2022)

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response
por: Niedelman, Wendy, et al.
Publicado: (2012)

Protein targets of thiazolidinone derivatives in Toxoplasma gondii and insights into their binding to ROP18
por: Molina, Diego, et al.
Publicado: (2018)

Detection of Toxoplasma gondii Infections using Virus-Like Particles Displaying T. gondii ROP4 Antigen
por: Kim, Min-Ju, et al.
Publicado: (2021)

A mechanistic study of Toxoplasma gondii ROP18 inhibiting differentiation of C17.2 neural stem cells
por: Zhang, Xian, et al.
Publicado: (2017)

A conserved ankyrin repeat-containing protein regulates conoid stability, motility and cell invasion in Toxoplasma gondii
por: Long, Shaojun, et al.
Publicado: (2017)

NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of Toxoplasma gondii in Naive Macrophages
por: Matta, Sumit K., et al.
Publicado: (2018)

Epitope analysis and protection by a ROP19 DNA vaccine against Toxoplasma gondii
por: Zhou, Jian, et al.
Publicado: (2016)

Screening and Identification of the Host Proteins Interacting with Toxoplasma gondii Rhoptry Protein ROP16
por: Pan, Ming, et al.
Publicado: (2017)

Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening
por: Yin, Kun, et al.
Publicado: (2019)

The Rhoptry Pseudokinase ROP54 Modulates Toxoplasma gondii Virulence and Host GBP2 Loading
por: Kim, Elliot W., et al.
Publicado: (2016)

Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii
por: Long, Shaojun, et al.
Publicado: (2017)

The Toxoplasma gondii protein ROP2 mediates host organelle association with the parasitophorous vacuole membrane
por: Sinai, Anthony P., et al.
Publicado: (2001)

Differential Impacts on Host Transcription by ROP and GRA Effectors from the Intracellular Parasite Toxoplasma gondii
por: Rastogi, Suchita, et al.
Publicado: (2020)

Toxoplasma gondii ROP16(I) Deletion: The Exacerbated Impact on Adverse Pregnant Outcomes in Mice
por: Cui, Wen, et al.
Publicado: (2020)

The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses
por: Chen, Longfei, et al.
Publicado: (2020)

ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence
por: Singh, Shishir, et al.
Publicado: (2023)

Calling in the Ca(V)alry—Toxoplasma gondii Hijacks GABAergic Signaling and Voltage-Dependent Calcium Channel Signaling for Trojan horse-Mediated Dissemination
por: Bhandage, Amol K., et al.
Publicado: (2019)

Mucosal Administration of Recombinant Baculovirus Displaying Toxoplasma gondii ROP4 Confers Protection Against T. gondii Challenge Infection in Mice
por: Yoon, Keon-Woong, et al.
Publicado: (2021)

Adjuvantic cytokine IL-33 improves the protective immunity of cocktailed DNA vaccine of ROP5 and ROP18 against toxoplasma gondii infection in mice
por: Zhu, Yu-Chao, et al.
Publicado: (2020)

ROP18-Mediated Transcriptional Reprogramming of HEK293T Cell Reveals New Roles of ROP18 in the Interplay Between Toxoplasma gondii and the Host Cell
por: Li, Jie-Xi, et al.
Publicado: (2020)

ATF6β is a host cellular target of the Toxoplasma gondii virulence factor ROP18
por: Yamamoto, Masahiro, et al.
Publicado: (2011)

ROP18 Is a Key Factor Responsible for Virulence Difference between Toxoplasma gondii and Neospora caninum
por: Lei, Tao, et al.
Publicado: (2014)

Influence of Two Major Toxoplasma Gondii Virulence Factors (ROP16 and ROP18) on the Immune Response of Peripheral Blood Mononuclear Cells to Human Toxoplasmosis Infection
por: Hernández-de-los-Ríos, Alejandro, et al.
Publicado: (2019)

Toxoplasma Actin Is Required for Efficient Host Cell Invasion
por: Drewry, Lisa L., et al.
Publicado: (2015)

Immune Protection of Rhoptry Protein 21 (ROP21) of Toxoplasma gondii as a DNA Vaccine Against Toxoplasmosis
por: Zhang, Zhenchao, et al.
Publicado: (2018)

Toxoplasma gondii virulence factor ROP1 reduces parasite susceptibility to murine and human innate immune restriction
por: Butterworth, Simon, et al.
Publicado: (2022)

ROP16-mediated activation of STAT6 enhances cyst development of type III Toxoplasma gondii in neurons
por: Kochanowsky, Joshua A., et al.
Publicado: (2023)

The Toxoplasma gondii rhoptry protein ROP18 is an Irga6‐specific kinase and regulated by the dense granule protein GRA7
por: Hermanns, Thomas, et al.
Publicado: (2015)

Rhoptry kinase protein 39 (ROP39) is a novel factor that recruits host mitochondria to the parasitophorous vacuole of Toxoplasma gondii
por: Fukumoto, Junpei, et al.
Publicado: (2021)

Protective efficacy of recombinant canine adenovirus type-2 expressing TgROP18 (CAV-2-ROP18) against acute and chronic Toxoplasma gondii infection in mice
por: Li, Xiu-Zhen, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_vgj9bml0389g73ssvt46df18el