Cargando…

Probucol, a “non-statin” cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice

Oxidative stress plays a vital role in the initiation and progression of age-related neurodegenerative diseases. Ameliorating oxidative damage is therefore considered as a beneficial strategy for the treatment of age-related neurodegenerative disorders. Probucol (Prob), a lipid-lowering prototype ag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Jin-Lan, Yu, Chao, Su, Min, Yang, Si-Man, Zhang, Fan, Chen, Yuan-Yuan, Liu, Jin-Yuan, Jiang, Yi-Fan, Zhong, Zhen-Guo, Wu, Deng-Pan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814622/ https://www.ncbi.nlm.nih.gov/pubmed/31590160 http://dx.doi.org/10.18632/aging.102337

Ejemplares similares

Probucol inhibits the initiation of atherosclerosis in cholesterol-fed rabbits
por: Niimi, Manabu, et al.
Publicado: (2013)

Probucol Prevents Diabetes-Induced Retinal Neuronal Degeneration through Upregulating Nrf2
por: Liu, Heng-Wei, et al.
Publicado: (2020)

Probucol alleviates atherosclerosis and improves high density lipoprotein function
por: Zhong, Jian-Kai, et al.
Publicado: (2011)

Effects of calcium dobesilate on Nrf2, Keap1 and HO-1 in the lenses of D-galactose-induced cataracts in rats
por: Sun, Jinfeng, et al.
Publicado: (2018)

Add-On Effect of Probucol in Atherosclerotic, Cholesterol-Fed Rabbits Treated with Atorvastatin
por: Keyamura, Yuka, et al.
Publicado: (2014)

Zhibaidihuang Decoction Ameliorates Cell Oxidative Stress by Regulating the Keap1-Nrf2-ARE Signalling Pathway
por: Wu, Pingping, et al.
Publicado: (2020)

A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ameliorates hydrogen peroxide-induced oxidative injury and apoptosis in osteoblasts
por: Zheng, Yue-huan, et al.
Publicado: (2021)

Nomilin targets the Keap1‐Nrf2 signalling and ameliorates the development of osteoarthritis
por: Xue, Xing‐He, et al.
Publicado: (2020)

Formononetin ameliorates oxaliplatin-induced peripheral neuropathy via the KEAP1-NRF2-GSTP1 axis
por: Fang, Yuan, et al.
Publicado: (2020)

Activation of the Nrf2/ARE signaling pathway by probucol contributes to inhibiting inflammation and neuronal apoptosis after spinal cord injury
por: Zhou, Zipeng, et al.
Publicado: (2017)

Agaricus bisporus Polysaccharides Ameliorates Behavioural Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota
por: Duan, Hui, et al.
Publicado: (2023)

Berberine ameliorates CCl(4)-induced liver injury in rats through regulation of the Nrf2-Keap1-ARE and p53 signaling pathways
por: Han, Chun-Yang, et al.
Publicado: (2019)

Quercetagetin alleviates zearalenone-induced liver injury in rabbits through Keap1/Nrf2/ARE signaling pathway
por: Wu, Fengyang, et al.
Publicado: (2023)

Keap1-Nrf2 signaling activation by Bardoxolone-methyl ameliorates high glucose-induced oxidative injury in human umbilical vein endothelial cells
por: Yang, Jing-Lei, et al.
Publicado: (2020)

Statins Lower Lipid Synthesis But Promote Secretion of Cholesterol-Enriched Extracellular Vesicles and Particles
por: Chen, Yundi, et al.
Publicado: (2022)

An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis
por: Lu, Meng-Chen, et al.
Publicado: (2016)

Oxyphylla A ameliorates cognitive deficits and alleviates neuropathology via the Akt-GSK3β and Nrf2-Keap1-HO-1 pathways in vitro and in vivo murine models of Alzheimer's disease
por: Bian, Yaqi, et al.
Publicado: (2021)

Racial Differences in the Cholesterol-Lowering Effect of Statin
por: Naito, Ryo, et al.
Publicado: (2017)

Bailcalin Protects against Diabetic Cardiomyopathy through Keap1/Nrf2/AMPK-Mediated Antioxidative and Lipid-Lowering Effects
por: Li, Ran, et al.
Publicado: (2019)

Keap1-Nrf2 Heterodimer: A Therapeutic Target to Ameliorate Sickle Cell Disease
por: Chauhan, Waseem, et al.
Publicado: (2023)

Probucol-induced hERG Channel Reduction can be Rescued by Matrine and Oxymatrine in vitro
por: Shi, Yuan-Qi, et al.
Publicado: (2019)

Statins redux: A re-assessment of how statins lower plasma cholesterol
por: Raghow, Rajendra
Publicado: (2017)

Role and Mechanism of Keap1/Nrf2 Signaling Pathway in the Regulation of Autophagy in Alleviating Pulmonary Fibrosis
por: Dong, Zhaoxing, et al.
Publicado: (2022)

The KEAP1–NRF2 System in Cancer
por: Taguchi, Keiko, et al.
Publicado: (2017)

Keap1/Nrf2 Signaling Pathway
por: Sykiotis, Gerasimos P.
Publicado: (2021)

Mechanisms underlying probucol-induced hERG-channel deficiency
por: Shi, Yuan-Qi, et al.
Publicado: (2015)

Anti-Inflammatory Effects of Statins Beyond Cholesterol Lowering
por: Joo, Seung-Jae
Publicado: (2012)

RHOA Is a Modulator of the Cholesterol-Lowering Effects of Statin
por: Medina, Marisa W., et al.
Publicado: (2012)

AR/PCC herb pair inhibits osteoblast pyroptosis to alleviate diabetes‐related osteoporosis by activating Nrf2/Keap1 pathway
por: Fu, Fangda, et al.
Publicado: (2023)

Leonurine ameliorates D-galactose-induced aging in mice through activation of the Nrf2 signalling pathway
por: Chen, Peng, et al.
Publicado: (2019)

Caffeic Acid Alleviates Memory and Hippocampal Neurogenesis Deficits in Aging Rats Induced by D-Galactose
por: Saenno, Rasa, et al.
Publicado: (2022)

DC32, a Dihydroartemisinin Derivative, Ameliorates Collagen-Induced Arthritis Through an Nrf2-p62-Keap1 Feedback Loop
por: Fan, Menglin, et al.
Publicado: (2018)

FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice
por: Tong, Gaozan, et al.
Publicado: (2023)

New Evidence of Probucol on Cardiovascular Events
por: Hirata, Ken-ichi
Publicado: (2021)

Isorhamnetin Alleviates Airway Inflammation by Regulating the Nrf2/Keap1 Pathway in a Mouse Model of COPD
por: Xu, Yifan, et al.
Publicado: (2022)

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
por: Fan, Z, et al.
Publicado: (2017)

Sedanolide Activates KEAP1–NRF2 Pathway and Ameliorates Hydrogen Peroxide-Induced Apoptotic Cell Death
por: Tabei, Yosuke, et al.
Publicado: (2023)

Structural basis of Keap1 interactions with Nrf2
por: Canning, Peter, et al.
Publicado: (2015)

Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals
por: Bhattacharjee, Shamee, et al.
Publicado: (2020)

The KEAP1/NRF2 Signaling Pathway in Keratinization
por: Ishitsuka, Yosuke, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qjjt876km3uik9qaaobs16cvf1