Identification of a monoclonal antibody that targets PD-1 in a manner requiring PD-1 Asn58 glycosylation

Programmed cell death 1 (PD-1) is inhibitory receptor and immune checkpoint protein. Blocking the interaction of PD-1 and its ligands PD-L1/ L2 is able to active T-cell-mediated antitumor response. Monoclonal antibody-based drugs targeting PD-1 pathway have exhibited great promise in cancer therapy....

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Detalles Bibliográficos
Autores principales: Wang, Mingzhu, Wang, Junchao, Wang, Rongjuan, Jiao, Shasha, Wang, Shuang, Zhang, Jinchao, Zhang, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814707/
https://www.ncbi.nlm.nih.gov/pubmed/31667366
http://dx.doi.org/10.1038/s42003-019-0642-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814707/
https://www.ncbi.nlm.nih.gov/pubmed/31667366
http://dx.doi.org/10.1038/s42003-019-0642-9

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