Biological process activity transformation of single cell gene expression for cross-species alignment

The maintenance and transition of cellular states are controlled by biological processes. Here we present a gene set-based transformation of single cell RNA-Seq data into biological process activities that provides a robust description of cellular states. Moreover, as these activities represent spec...

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Detalles Bibliográficos
Autores principales: Ding, Hongxu, Blair, Andrew, Yang, Ying, Stuart, Joshua M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814736/
https://www.ncbi.nlm.nih.gov/pubmed/31653878
http://dx.doi.org/10.1038/s41467-019-12924-w
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author Ding, Hongxu
Blair, Andrew
Yang, Ying
Stuart, Joshua M.
author_facet Ding, Hongxu
Blair, Andrew
Yang, Ying
Stuart, Joshua M.
author_sort Ding, Hongxu
collection PubMed
description The maintenance and transition of cellular states are controlled by biological processes. Here we present a gene set-based transformation of single cell RNA-Seq data into biological process activities that provides a robust description of cellular states. Moreover, as these activities represent species-independent descriptors, they facilitate the alignment of single cell states across different organisms.
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spelling pubmed-68147362019-10-28 Biological process activity transformation of single cell gene expression for cross-species alignment Ding, Hongxu Blair, Andrew Yang, Ying Stuart, Joshua M. Nat Commun Article The maintenance and transition of cellular states are controlled by biological processes. Here we present a gene set-based transformation of single cell RNA-Seq data into biological process activities that provides a robust description of cellular states. Moreover, as these activities represent species-independent descriptors, they facilitate the alignment of single cell states across different organisms. Nature Publishing Group UK 2019-10-25 /pmc/articles/PMC6814736/ /pubmed/31653878 http://dx.doi.org/10.1038/s41467-019-12924-w Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ding, Hongxu
Blair, Andrew
Yang, Ying
Stuart, Joshua M.
Biological process activity transformation of single cell gene expression for cross-species alignment
title Biological process activity transformation of single cell gene expression for cross-species alignment
title_full Biological process activity transformation of single cell gene expression for cross-species alignment
title_fullStr Biological process activity transformation of single cell gene expression for cross-species alignment
title_full_unstemmed Biological process activity transformation of single cell gene expression for cross-species alignment
title_short Biological process activity transformation of single cell gene expression for cross-species alignment
title_sort biological process activity transformation of single cell gene expression for cross-species alignment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814736/
https://www.ncbi.nlm.nih.gov/pubmed/31653878
http://dx.doi.org/10.1038/s41467-019-12924-w
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