Wnt5a induces ROR1 to recruit cortactin to promote breast-cancer migration and metastasis

ROR1 is a conserved oncoembryonic surface protein expressed in breast cancer. Here we report that ROR1 associates with cortactin in primary breast-cancer cells or in MCF7 transfected to express ROR1. Wnt5a also induced ROR1-dependent tyrosine phosphorylation of cortactin (Y421), which recruited ARHG...

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Detalles Bibliográficos
Autores principales: Hasan, Md Kamrul, Widhopf, George F., Zhang, Suping, Lam, Sharon M., Shen, Zhouxin, Briggs, Steven P., Parker, Barbara A., Kipps, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814774/
https://www.ncbi.nlm.nih.gov/pubmed/31667337
http://dx.doi.org/10.1038/s41523-019-0131-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814774/
https://www.ncbi.nlm.nih.gov/pubmed/31667337
http://dx.doi.org/10.1038/s41523-019-0131-9

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