Dormant pathogenic CD4(+) T cells are prevalent in the peripheral repertoire of healthy mice

Thymic central tolerance eliminates most immature T cells with autoreactive T cell receptors (TCR) that recognize self MHC/peptide complexes. Regardless, an unknown number of autoreactive CD4(+)Foxp3(−) T cells escape negative selection and in the periphery require continuous suppression by CD4(+)Fo...

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Detalles Bibliográficos
Autores principales: Cebula, Anna, Kuczma, Michal, Szurek, Edyta, Pietrzak, Maciej, Savage, Natasha, Elhefnawy, Wessam R., Rempala, Grzegorz, Kraj, Piotr, Ignatowicz, Leszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814812/
https://www.ncbi.nlm.nih.gov/pubmed/31653839
http://dx.doi.org/10.1038/s41467-019-12820-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814812/
https://www.ncbi.nlm.nih.gov/pubmed/31653839
http://dx.doi.org/10.1038/s41467-019-12820-3

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