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Dormant pathogenic CD4(+) T cells are prevalent in the peripheral repertoire of healthy mice
Thymic central tolerance eliminates most immature T cells with autoreactive T cell receptors (TCR) that recognize self MHC/peptide complexes. Regardless, an unknown number of autoreactive CD4(+)Foxp3(−) T cells escape negative selection and in the periphery require continuous suppression by CD4(+)Fo...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814812/ https://www.ncbi.nlm.nih.gov/pubmed/31653839 http://dx.doi.org/10.1038/s41467-019-12820-3 |