PROTAC induced-BET protein degradation exhibits potent anti-osteosarcoma activity by triggering apoptosis

Targeting oncogenic proteins for degradation using proteolysis-targeting chimera (PROTAC) recently has drawn increasing attention in the field of cancer research. Bromodomain and extra-terminal (BET) family proteins are newly identified cancer-related epigenetic regulators, which have a role in the...

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Detalles Bibliográficos
Autores principales: Shi, Chengcheng, Zhang, Huapeng, Wang, Penglei, Wang, Kai, Xu, Denghui, Wang, Haitao, Yin, Li, Zhang, Shuijun, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814818/
https://www.ncbi.nlm.nih.gov/pubmed/31653826
http://dx.doi.org/10.1038/s41419-019-2022-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814818/
https://www.ncbi.nlm.nih.gov/pubmed/31653826
http://dx.doi.org/10.1038/s41419-019-2022-2

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