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PROTAC induced-BET protein degradation exhibits potent anti-osteosarcoma activity by triggering apoptosis
Targeting oncogenic proteins for degradation using proteolysis-targeting chimera (PROTAC) recently has drawn increasing attention in the field of cancer research. Bromodomain and extra-terminal (BET) family proteins are newly identified cancer-related epigenetic regulators, which have a role in the...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814818/ https://www.ncbi.nlm.nih.gov/pubmed/31653826 http://dx.doi.org/10.1038/s41419-019-2022-2 |