Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer

We construct risk predictors using polygenic scores (PGS) computed from common Single Nucleotide Polymorphisms (SNPs) for a number of complex disease conditions, using L1-penalized regression (also known as LASSO) on case-control data from UK Biobank. Among the disease conditions studied are Hypothy...

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Detalles Bibliográficos
Autores principales: Lello, Louis, Raben, Timothy G., Yong, Soke Yuen, Tellier, Laurent C. A. M., Hsu, Stephen D. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814833/
https://www.ncbi.nlm.nih.gov/pubmed/31653892
http://dx.doi.org/10.1038/s41598-019-51258-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814833/
https://www.ncbi.nlm.nih.gov/pubmed/31653892
http://dx.doi.org/10.1038/s41598-019-51258-x

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