Late-stage trifluoromethylthiolation of benzylic C-H bonds

The benzylic positions in drugs are sites that readily react with cytochrome P450 oxidases via single-electron oxidation. New synthetic methodologies to incorporate a fluoroalkyl group at the benzylic site are continually being developed, and in this paper, we report a metal-free and site-selective...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Wentao, Wang, Wenliang, Liu, Tao, Xie, Jin, Zhu, Chengjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814834/
https://www.ncbi.nlm.nih.gov/pubmed/31653853
http://dx.doi.org/10.1038/s41467-019-12844-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814834/
https://www.ncbi.nlm.nih.gov/pubmed/31653853
http://dx.doi.org/10.1038/s41467-019-12844-9

Ejemplares similares