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Late-stage trifluoromethylthiolation of benzylic C-H bonds

The benzylic positions in drugs are sites that readily react with cytochrome P450 oxidases via single-electron oxidation. New synthetic methodologies to incorporate a fluoroalkyl group at the benzylic site are continually being developed, and in this paper, we report a metal-free and site-selective...

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Detalles Bibliográficos
Autores principales:	Xu, Wentao, Wang, Wenliang, Liu, Tao, Xie, Jin, Zhu, Chengjian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814834/ https://www.ncbi.nlm.nih.gov/pubmed/31653853 http://dx.doi.org/10.1038/s41467-019-12844-9

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