IL-21 regulates SOCS1 expression in autoreactive CD8(+) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice

In type 1 diabetes, maturation of activated autoreactive CD8(+) T cells to fully armed effector cytotoxic T lymphocytes (CTL) occurs within the islet. At present the signals required for the maturation process are poorly defined. Cytokines could potentially provide the necessary “third signal” requi...

Descripción completa

Detalles Bibliográficos
Autores principales: Sutherland, Andrew P. R., Graham, Kate L., Papadimitriou, Michelle, Jhala, Gaurang, Trivedi, Prerak, Catterall, Tara, Fynch, Stacey, Kay, Thomas W. H., Thomas, Helen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814838/
https://www.ncbi.nlm.nih.gov/pubmed/31653894
http://dx.doi.org/10.1038/s41598-019-51636-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814838/
https://www.ncbi.nlm.nih.gov/pubmed/31653894
http://dx.doi.org/10.1038/s41598-019-51636-5

Ejemplares similares