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IL-21 regulates SOCS1 expression in autoreactive CD8(+) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice

In type 1 diabetes, maturation of activated autoreactive CD8(+) T cells to fully armed effector cytotoxic T lymphocytes (CTL) occurs within the islet. At present the signals required for the maturation process are poorly defined. Cytokines could potentially provide the necessary “third signal” requi...

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Detalles Bibliográficos
Autores principales:	Sutherland, Andrew P. R., Graham, Kate L., Papadimitriou, Michelle, Jhala, Gaurang, Trivedi, Prerak, Catterall, Tara, Fynch, Stacey, Kay, Thomas W. H., Thomas, Helen E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814838/ https://www.ncbi.nlm.nih.gov/pubmed/31653894 http://dx.doi.org/10.1038/s41598-019-51636-5

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