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Fitness effects but no temperature-mediated balancing selection at the polymorphic Adh gene of Drosophila melanogaster

Polymorphism in the alcohol dehydrogenase (ADH) protein of Drosophila melanogaster, like genetic variation in many other enzymes, has long been hypothesized to be maintained by a selective trade-off between thermostability and enzyme activity. Two major Adh variants, named Fast and Slow, are distrib...

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Detalles Bibliográficos
Autores principales: Siddiq, Mohammad A., Thornton, Joseph W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815130/
https://www.ncbi.nlm.nih.gov/pubmed/31594844
http://dx.doi.org/10.1073/pnas.1909216116